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Форум » Test category » Test forum » MlisoMekhe
MlisoMekheДата: Среда, 08.04.2015, 20:48 | Сообщение # 1
Группа: Гости

The objective of this article is to review evidence supporting the efficacy and safety of dapoxetine in the treatment of PE. This search was then manually cross referenced for all papers. This review encompasses studies of dapoxetine pharmacokinetics, animal studies, human phase I, II and III studies, independent postmarketing and pharmacovigilance efficacy and safety studies and drug-interaction studies. <a href=>Dapoxetine rezeptfrei kaufen</a> is a potent SSRI which is administered on demand 1–3 h prior to planned sexual contact. It is rapidly absorbed and eliminated, resulting in minimal accumulation, and has dose-proportional pharmacokinetics which are unaffected by multiple dosing. Dapoxetine 30 mg and 60 mg has been evaluated in five industry-sponsored randomized, double-blind, placebo-controlled studies in 6081 men aged at least 18 years. Outcome measures included stopwatch-measured intravaginal ejaculatory latency time (IELT), Premature Ejaculation Profile (PEP) inventory items, Clinical Global Impression of Change (CGIC) in PE, and adverse events. Mean IELT, all PEP items and CGIC improved significantly with both doses of dapoxetine versus placebo (all p <0.001). The most common treatment-related adverse effects included nausea (11.0% for 30 mg, 22.2% for 60 mg), dizziness (5.9% for 30 mg, 10.9% for 60 mg), and headache (5.6% for 30 mg, 8.8% for 60 mg), and evaluation of validated rated scales demonstrated no SSRI class-related effects with dapoxetine use. Dapoxetine, as the first drug developed for PE, is an effective and safe treatment for PE and represents a major advance in sexual medicine.

Dapoxetine is indicated for the treatment of premature ejaculation (PE) in adult men aged 18 to 64 years.

Dapoxetine should only be prescribed to patients who meet all the following criteria:

• An intravaginal ejaculatory latency time (IELT) of less than two minutes; and

• Persistent or recurrent ejaculation with minimal sexual stimulation before, on, or shortly after penetration and before the patient wishes; and

• Marked personal distress or interpersonal difficulty as a consequence of PE; and

• Poor control over ejaculation; and

• A history of premature ejaculation in the majority of intercourse attempts over the prior 6 months.

Dapoxetine should be administered only as on-demand treatment before anticipated sexual activity. Dapoxetine should not be prescribed to delay ejaculation in men who have not been diagnosed with PE.

4.2 Posology and method of administration


Adult men (aged 18 to 64 years)

The recommended starting dose for all patients is 30 mg, taken as needed approximately 1 to 3 hours prior to sexual activity. Treatment with Dapoxetine should not be initiated with the 60 mg dose.

Dapoxetine is not intended for continuous daily use. Dapoxetine should be taken only when sexual activity is anticipated. Dapoxetine must not be taken more frequently than once every 24 hours.

If the individual response to 30 mg is insufficient and the patient has not experienced moderate or severe adverse reactions or prodromal symptoms suggestive of syncope, the dose may be increased to a maximum recommended dose of 60 mg taken as needed approximately 1 to 3 hours prior to sexual activity. The incidence and severity of adverse events is higher with the 60 mg dose.

A careful appraisal of individual benefit risk of Dapoxetine should be performed by the physician after the first four weeks of treatment (or at least after 6 doses of treatment) to determine whether continuing treatment with Dapoxetine is appropriate.
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